parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in macrophages	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 141	0.82
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 7954

receipt 7962: STAB1 in dopamine neurons, braak

power: full sample -0.49 (p 0.037, n 18), 95% CI -0.78 to -0.04. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.48 (p 0.043, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.63 (p 0.0051, n 18). not the mix.
skeptic: leave-one-out range -0.60 to -0.43, sign flips 0; without severely affected donors -0.49 (p 0.037, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for STAB1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7961: STAB1 in microglia, braak

power: full sample -0.56 (p 0.016, n 18), 95% CI -0.81 to -0.13. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.49 (p 0.037, n 18). holds up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.49 (p 0.037, n 18). not the mix.
skeptic: leave-one-out range -0.74 to -0.50, sign flips 0; without severely affected donors -0.56 (p 0.016, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for STAB1 in microglia.

case closed: nothing better to follow up.

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