parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.06 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in kupffer cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	3 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 4365

SLC7A7 in dopamine neurons, braak-0.32 (p 0.400) → -0.10 (p 0.807)receipt 4372
SLC7A7 in microglia, braak-0.11 (p 0.770) → -0.45 (p 0.227)receipt 4371

receipt 4372: SLC7A7 in dopamine neurons, braak

power: full sample -0.21 (p 0.398, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.25 (p 0.319, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.33 (p 0.182, n 18). could be the mix.
skeptic: leave-one-out range -0.32 to -0.10, sign flips 0; without severely affected donors -0.21 (p 0.398, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SLC7A7 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4371: SLC7A7 in microglia, braak

power: full sample -0.33 (p 0.188, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.29 (p 0.243, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.31 (p 0.211, n 18). could be the mix.
skeptic: leave-one-out range -0.48 to -0.23, sign flips 0; without severely affected donors -0.33 (p 0.188, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SLC7A7 in microglia.

case closed: nothing better to follow up.

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