Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in thyrotrophs | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 22 | 0.82 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8428
Sealed predictions
- SLC25A27 in dopamine neurons, braak+0.41 (p 0.273) → -0.32 (p 0.400)receipt 8437
- SLC25A27 in oligodendrocytes, braak+0.04 (p 0.927) → -0.15 (p 0.699)receipt 8436
Swarm cases
receipt 8437: SLC25A27 in dopamine neurons, braak
- power
- full sample +0.13 (p 0.603, n 18), 95% CI -0.36 to +0.56. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.12 (p 0.633, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.15 (p 0.549, n 18). could be the mix.
- skeptic
- leave-one-out range +0.02 to +0.24, sign flips 0; without severely affected donors +0.13 (p 0.603, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC25A27 in dopamine neurons.
case closed: nothing better to follow up.
receipt 8436: SLC25A27 in oligodendrocytes, braak
- power
- full sample -0.05 (p 0.834, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.07 (p 0.787, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.10 (p 0.702, n 18). could be the mix.
- skeptic
- leave-one-out range -0.17 to +0.09, sign flips 4; without severely affected donors -0.05 (p 0.834, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SLC25A27 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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