parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in astrocytes (478 nCPM)	1.00
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	2 Parkinson's papers of 133	0.85
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 9352

SLC14A1 in dopamine neurons, braak-0.18 (p 0.639) → +0.16 (p 0.680)receipt 9360
SLC14A1 in astrocytes, braak-0.18 (p 0.639) → -0.12 (p 0.749)receipt 9359

receipt 9360: SLC14A1 in dopamine neurons, braak

power: full sample -0.04 (p 0.881, n 18), 95% CI -0.50 to +0.44. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.02 (p 0.949, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.11 (p 0.677, n 18). could be the mix.
skeptic: leave-one-out range -0.17 to +0.11, sign flips 5; without severely affected donors -0.04 (p 0.881, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SLC14A1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 9359: SLC14A1 in astrocytes, braak

power: full sample -0.16 (p 0.532, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.16 (p 0.532, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.10 (p 0.690, n 18). could be the mix.
skeptic: leave-one-out range -0.29 to -0.03, sign flips 0; without severely affected donors -0.16 (p 0.532, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SLC14A1 in astrocytes.

case closed: nothing better to follow up.

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