Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 286 | 0.85 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11849
Sealed predictions
- SERPINH1 in dopamine neurons, braak-0.26 (p 0.493) → -0.58 (p 0.102)receipt 11856
Swarm cases
receipt 11856: SERPINH1 in dopamine neurons, braak
- power
- full sample -0.39 (p 0.105, n 18), 95% CI -0.73 to +0.09. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.47 (p 0.050, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.53 (p 0.023, n 18). not the mix.
- skeptic
- leave-one-out range -0.52 to -0.31, sign flips 0; without severely affected donors -0.39 (p 0.105, n 18). fragile.
- cell type
- strongest in microglia: -0.66 (p 0.0028, n 18) vs -0.39 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SERPINH1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SERPINH1 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.38 p 0.183 (needs p < 1.9e-4)
Receipts
loading the receipts