parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in cdc	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 13569

SERPINB9 in dopamine neurons, braak+0.01 (p 0.981) → +0.13 (p 0.741)receipt 13576
SERPINB9 in microglia, braak-0.24 (p 0.533) → +0.51 (p 0.160)receipt 13575

receipt 13576: SERPINB9 in dopamine neurons, braak

power: full sample -0.26 (p 0.306, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.337, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.28 (p 0.258, n 18). could be the mix.
skeptic: leave-one-out range -0.41 to -0.16, sign flips 0; without severely affected donors -0.26 (p 0.306, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SERPINB9 in dopamine neurons.

case closed: nothing better to follow up.

receipt 13575: SERPINB9 in microglia, braak

power: full sample +0.09 (p 0.735, n 18), 95% CI -0.40 to +0.53. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.03 (p 0.922, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.01 (p 0.983, n 18). could be the mix.
skeptic: leave-one-out range -0.03 to +0.26, sign flips 3; without severely affected donors +0.09 (p 0.735, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SERPINB9 in microglia.

case closed: nothing better to follow up.

loading the receipts