Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in oligodendrocytes (18 nCPM) | 1.00 |
| chemistry Open Targets | a small-molecule pocket | 0.50 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 3 Parkinson's papers of 275 | 0.82 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 9341
Sealed predictions
- SEMA7A in dopamine neurons, braak-0.21 (p 0.583) → +0.33 (p 0.388)receipt 9351
- SEMA7A in oligodendrocytes, braak+0.02 (p 0.965) → -0.87 (p 0.002)receipt 9350
Swarm cases
receipt 9351: SEMA7A in dopamine neurons, braak
- power
- full sample -0.23 (p 0.355, n 18), 95% CI -0.63 to +0.26. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.23 (p 0.355, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.24 (p 0.346, n 18). could be the mix.
- skeptic
- leave-one-out range -0.39 to -0.14, sign flips 0; without severely affected donors -0.23 (p 0.355, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.59 (p 0.0092, n 18) vs -0.23 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SEMA7A in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up SEMA7A · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.00 p 1.000 (needs p < 2.3e-4)
receipt 9350: SEMA7A in oligodendrocytes, braak
- power
- full sample -0.59 (p 0.0092, n 18), 95% CI -0.83 to -0.18. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.60 (p 0.0080, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.63 (p 0.0047, n 18). not the mix.
- skeptic
- leave-one-out range -0.67 to -0.54, sign flips 0; without severely affected donors -0.59 (p 0.0092, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SEMA7A in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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