Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in neutrophils | 0.75 |
| chemistry Open Targets | compounds already reach it: pepinemab | 0.81 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 453 | 0.85 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 13114
Sealed predictions
- SEMA4D in dopamine neurons, braak-0.14 (p 0.716) → -0.38 (p 0.308)receipt 13122
- SEMA4D in oligodendrocytes, braak-0.17 (p 0.654) → -0.41 (p 0.273)receipt 13121
Swarm cases
receipt 13122: SEMA4D in dopamine neurons, braak
- power
- full sample -0.27 (p 0.285, n 18), 95% CI -0.65 to +0.23. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.315, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.26 (p 0.306, n 18). could be the mix.
- skeptic
- leave-one-out range -0.44 to -0.19, sign flips 0; without severely affected donors -0.27 (p 0.285, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SEMA4D in dopamine neurons.
case closed: nothing better to follow up.
receipt 13121: SEMA4D in oligodendrocytes, braak
- power
- full sample -0.26 (p 0.298, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.239, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.34 (p 0.170, n 18). could be the mix.
- skeptic
- leave-one-out range -0.41 to -0.15, sign flips 0; without severely affected donors -0.26 (p 0.298, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for SEMA4D in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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