parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.02 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including oligodendrocytes; strongest in renal collecting duct intercalated cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	16 Parkinson's papers of 1,312	0.63
pathways Reactome	3 pathways; mostly mitochondrial quality control	1.00

No case: the score is under the bar. Receipt 8566

receipt 8574: SDHA in dopamine neurons, braak

power: full sample +0.19 (p 0.439, n 18), 95% CI -0.30 to +0.61. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.19 (p 0.444, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.20 (p 0.424, n 18). could be the mix.
skeptic: leave-one-out range +0.14 to +0.36, sign flips 0; without severely affected donors +0.19 (p 0.439, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SDHA in dopamine neurons.

case closed: nothing better to follow up.

receipt 8573: SDHA in oligodendrocytes, braak

power: full sample +0.47 (p 0.051, n 18), 95% CI -0.00 to +0.77. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.59 (p 0.0095, n 18). holds up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.64 (p 0.0042, n 18). not the mix.
skeptic: leave-one-out range +0.40 to +0.56, sign flips 0; without severely affected donors +0.47 (p 0.051, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for SDHA in oligodendrocytes.

case closed: nothing better to follow up.

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