Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 12198
Sealed predictions
- RUSC1 in dopamine neurons, braak+0.37 (p 0.329) → -0.55 (p 0.122)receipt 12205
Swarm cases
receipt 12205: RUSC1 in dopamine neurons, braak
- power
- full sample -0.09 (p 0.735, n 18), 95% CI -0.53 to +0.40. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.04 (p 0.881, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.08 (p 0.761, n 18). could be the mix.
- skeptic
- leave-one-out range -0.24 to +0.05, sign flips 1; without severely affected donors -0.09 (p 0.735, n 18). fragile.
- cell type
- strongest in OPCs: -0.66 (p 0.0031, n 18) vs -0.09 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RUSC1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up RUSC1 · OPCs · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.30 p 0.286 (needs p < 1.8e-4)
Receipts
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