Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.32 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.24 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 1148
Sealed predictions
- RPS6KC1 in dopamine neurons, braak+0.41 (p 0.273) → +0.32 (p 0.402)receipt 1153
Swarm cases
receipt 1153: RPS6KC1 in dopamine neurons, braak
- power
- full sample +0.40 (p 0.103, n 18), 95% CI -0.09 to +0.73. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.52 (p 0.027, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.53 (p 0.023, n 18). not the mix.
- skeptic
- leave-one-out range +0.33 to +0.52, sign flips 0; without severely affected donors +0.40 (p 0.103, n 18). fragile.
- cell type
- strongest in astrocytes: -0.68 (p 0.0019, n 18) vs +0.40 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RPS6KC1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up RPS6KC1 · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.10 p 0.722 (needs p < 0.0011)
Receipts
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