Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.02 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 65 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 7909
Sealed predictions
- RNF128 in dopamine neurons, braak+0.21 (p 0.581) → +0.42 (p 0.255)receipt 7917
Swarm cases
receipt 7917: RNF128 in dopamine neurons, braak
- power
- full sample +0.28 (p 0.258, n 18), 95% CI -0.21 to +0.66. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.39 (p 0.109, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.47 (p 0.049, n 18). not the mix.
- skeptic
- leave-one-out range +0.18 to +0.44, sign flips 0; without severely affected donors +0.28 (p 0.258, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RNF128 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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