parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.10 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in platelets	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	13 Parkinson's papers of 136	0.65
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 2598

receipt 2606: RGS10 in dopamine neurons, braak

power: full sample -0.49 (p 0.039, n 18), 95% CI -0.78 to -0.03. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.56 (p 0.016, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.014, n 18). not the mix.
skeptic: leave-one-out range -0.60 to -0.41, sign flips 0; without severely affected donors -0.49 (p 0.039, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RGS10 in dopamine neurons.

case closed: nothing better to follow up.

receipt 2605: RGS10 in microglia, braak

power: full sample -0.23 (p 0.369, n 18), 95% CI -0.63 to +0.27. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.337, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.10 (p 0.690, n 18). could be the mix.
skeptic: leave-one-out range -0.30 to -0.11, sign flips 0; without severely affected donors -0.23 (p 0.369, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for RGS10 in microglia.

case closed: nothing better to follow up.

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