Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 41 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 17156
Sealed predictions
- RAP1GDS1 in dopamine neurons, braak+0.00 (p 1.000) → +0.11 (p 0.778)receipt 17163
Swarm cases
receipt 17163: RAP1GDS1 in dopamine neurons, braak
- power
- full sample +0.06 (p 0.800, n 18), 95% CI -0.42 to +0.52. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.09 (p 0.715, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.12 (p 0.646, n 18). could be the mix.
- skeptic
- leave-one-out range -0.05 to +0.19, sign flips 3; without severely affected donors +0.06 (p 0.800, n 18). fragile.
- cell type
- strongest in astrocytes: +0.61 (p 0.0072, n 18) vs +0.06 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAP1GDS1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up RAP1GDS1 · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.50 p 0.076 (needs p < 1.3e-4)
Receipts
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