Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in megakaryocytes | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 16231
Sealed predictions
- RAB33A in oligodendrocytes, braak-0.37 (p 0.329) → -0.04 (p 0.911)receipt 16238
- RAB33A in dopamine neurons, braak-0.33 (p 0.385) → -0.01 (p 0.982)receipt 16239
Swarm cases
receipt 16239: RAB33A in dopamine neurons, braak
- power
- full sample -0.10 (p 0.702, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.09 (p 0.709, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.11 (p 0.652, n 18). could be the mix.
- skeptic
- leave-one-out range -0.19 to +0.04, sign flips 2; without severely affected donors -0.10 (p 0.702, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAB33A in dopamine neurons.
case closed: nothing better to follow up.
receipt 16238: RAB33A in oligodendrocytes, braak
- power
- full sample -0.18 (p 0.476, n 18), 95% CI -0.60 to +0.31. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.18 (p 0.476, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.17 (p 0.504, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.08, sign flips 0; without severely affected donors -0.18 (p 0.476, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for RAB33A in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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