Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain inhibitory neurons; strongest in rod photoreceptor cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | 12 Parkinson's trials, 2 stopped | 0.87 |
| literature PubMed | 206 Parkinson's papers of 13,182 | 0.30 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 14911
Sealed predictions
- PSD in dopamine neurons, braak-0.23 (p 0.553) → -0.04 (p 0.927)receipt 14919
Swarm cases
receipt 14919: PSD in dopamine neurons, braak
- power
- full sample -0.19 (p 0.444, n 18), 95% CI -0.60 to +0.30. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.27 (p 0.281, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.41 (p 0.093, n 18). could be the mix.
- skeptic
- leave-one-out range -0.33 to -0.09, sign flips 0; without severely affected donors -0.19 (p 0.444, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PSD in dopamine neurons.
case closed: nothing better to follow up.
Receipts
loading the receipts