Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 7 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 16571
Sealed predictions
- PRR5 in dopamine neurons, braak-0.24 (p 0.539) → -0.42 (p 0.258)receipt 16580
- PRR5 in astrocytes, braak-0.57 (p 0.108) → -0.24 (p 0.530)receipt 16579
Swarm cases
receipt 16580: PRR5 in dopamine neurons, braak
- power
- full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.161, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.38 (p 0.116, n 18). could be the mix.
- skeptic
- leave-one-out range -0.47 to -0.26, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
- cell type
- strongest in microglia: -0.65 (p 0.0036, n 18) vs -0.35 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRR5 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PRR5 · microglia · braak: substantia nigra, an independent cohort (already registered)
receipt 16579: PRR5 in astrocytes, braak
- power
- full sample -0.32 (p 0.194, n 18), 95% CI -0.69 to +0.17. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.31 (p 0.204, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.37 (p 0.130, n 18). could be the mix.
- skeptic
- leave-one-out range -0.48 to -0.24, sign flips 0; without severely affected donors -0.32 (p 0.194, n 18). fragile.
- cell type
- strongest in microglia: -0.65 (p 0.0036, n 18) vs -0.32 in astrocytes. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRR5 in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PRR5 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.75 p 0.0077 (needs p < 1.4e-4)
Receipts
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