Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in hematopoietic stem cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 5 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 12102
Sealed predictions
- PRKG2 in oligodendrocytes, braak+0.05 (p 0.891) → -0.31 (p 0.414)receipt 12110
- PRKG2 in dopamine neurons, braak+0.35 (p 0.360) → +0.51 (p 0.160)receipt 12111
Swarm cases
receipt 12111: PRKG2 in dopamine neurons, braak
- power
- full sample +0.44 (p 0.066, n 18), 95% CI -0.03 to +0.75. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.44 (p 0.067, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.067, n 18). could be the mix.
- skeptic
- leave-one-out range +0.36 to +0.62, sign flips 0; without severely affected donors +0.44 (p 0.066, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRKG2 in dopamine neurons.
case closed: nothing better to follow up.
receipt 12110: PRKG2 in oligodendrocytes, braak
- power
- full sample -0.04 (p 0.888, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.06 (p 0.800, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.04 (p 0.881, n 18). could be the mix.
- skeptic
- leave-one-out range -0.15 to +0.09, sign flips 4; without severely affected donors -0.04 (p 0.888, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PRKG2 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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