Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PPP1R14A

protein phosphatase 1 regulatory inhibitor subunit 14A

translation score 0.45, read 2026-10-30; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in megakaryocytes0.75
chemistry
Open Targets		hard to drug0.00
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 14792

Sealed predictions

  1. PPP1R14A in dopamine neurons, braak+0.75 (p 0.019) → -0.45 (p 0.230)receipt 14799
  2. PPP1R14A in oligodendrocytes, braak+0.25 (p 0.517) → -0.41 (p 0.276)receipt 14798

Swarm cases

receipt 14799: PPP1R14A in dopamine neurons, braak

power
full sample +0.15 (p 0.544, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.12 (p 0.627, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.355, n 18). could be the mix.
skeptic
leave-one-out range +0.04 to +0.30, sign flips 0; without severely affected donors +0.15 (p 0.544, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PPP1R14A in dopamine neurons.

case closed: nothing better to follow up.

receipt 14798: PPP1R14A in oligodendrocytes, braak

power
full sample -0.07 (p 0.794, n 18), 95% CI -0.52 to +0.41. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.18 (p 0.465, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.22 (p 0.374, n 18). could be the mix.
skeptic
leave-one-out range -0.20 to +0.04, sign flips 4; without severely affected donors -0.07 (p 0.794, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PPP1R14A in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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