Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including brain excitatory neurons; strongest in cone photoreceptor cells | 0.75 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 13147
Sealed predictions
- PPM1E in dopamine neurons, braak+0.38 (p 0.309) → +0.40 (p 0.288)receipt 13155
Swarm cases
receipt 13155: PPM1E in dopamine neurons, braak
- power
- full sample +0.37 (p 0.127, n 18), 95% CI -0.11 to +0.72. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.37 (p 0.132, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.44 (p 0.064, n 18). could be the mix.
- skeptic
- leave-one-out range +0.29 to +0.49, sign flips 0; without severely affected donors +0.37 (p 0.127, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPM1E in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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