Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 6 Parkinson's papers of 322 | 0.74 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 8812
Sealed predictions
- PPID in dopamine neurons, braak+0.56 (p 0.115) → +0.41 (p 0.273)receipt 8819
Swarm cases
receipt 8819: PPID in dopamine neurons, braak
- power
- full sample +0.52 (p 0.028, n 18), 95% CI +0.07 to +0.79. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: +0.48 (p 0.042, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.45 (p 0.059, n 18). could be the mix.
- skeptic
- leave-one-out range +0.45 to +0.59, sign flips 0; without severely affected donors +0.52 (p 0.028, n 18). robust.
- cell type
- strongest in astrocytes: +0.64 (p 0.0039, n 18) vs +0.52 in dopamine neurons. proposing astrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PPID in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up PPID · astrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.57 p 0.041 (needs p < 2.4e-4)
Receipts
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