Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocytes; strongest in cardiomyocytes | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 7 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 13822
Sealed predictions
- POLR3G in dopamine neurons, braak-0.48 (p 0.195) → +0.60 (p 0.090)receipt 13830
- POLR3G in oligodendrocytes, braak+0.08 (p 0.838) → +0.80 (p 0.010)receipt 13829
Swarm cases
receipt 13830: POLR3G in dopamine neurons, braak
- power
- full sample +0.24 (p 0.328, n 18), 95% CI -0.25 to +0.64. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.30 (p 0.228, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.30 (p 0.221, n 18). could be the mix.
- skeptic
- leave-one-out range +0.15 to +0.36, sign flips 0; without severely affected donors +0.24 (p 0.328, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for POLR3G in dopamine neurons.
case closed: nothing better to follow up.
receipt 13829: POLR3G in oligodendrocytes, braak
- power
- full sample +0.31 (p 0.204, n 18), 95% CI -0.18 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.29 (p 0.250, n 18). does not hold up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.26 (p 0.294, n 18). could be the mix.
- skeptic
- leave-one-out range +0.23 to +0.46, sign flips 0; without severely affected donors +0.31 (p 0.204, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for POLR3G in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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