Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in other brain neurons (130 nCPM) | 1.00 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | 12 Parkinson's trials, 0 stopped | 1.00 |
| literature PubMed | 1 Parkinson's papers of 34 | 0.91 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 11951
Sealed predictions
- PNMA2 in dopamine neurons, braak+0.00 (p 1.000) → +0.13 (p 0.735)receipt 11958
Swarm cases
receipt 11958: PNMA2 in dopamine neurons, braak
- power
- full sample +0.14 (p 0.573, n 18), 95% CI -0.35 to +0.57. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.10 (p 0.690, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.204, n 18). could be the mix.
- skeptic
- leave-one-out range +0.03 to +0.28, sign flips 0; without severely affected donors +0.14 (p 0.573, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PNMA2 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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