parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in epicardial cells	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	3 Parkinson's papers of 308	0.82
pathways Reactome	35 pathways; mostly growth signalling	0.60

No case: the score is under the bar. Receipt 5193

receipt 5202: PLCG1 in dopamine neurons, braak

power: full sample -0.49 (p 0.041, n 18), 95% CI -0.78 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.47 (p 0.049, n 18). holds up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.57 (p 0.014, n 18). not the mix.
skeptic: leave-one-out range -0.58 to -0.42, sign flips 0; without severely affected donors -0.49 (p 0.041, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PLCG1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 5201: PLCG1 in astrocytes, braak

power: full sample +0.18 (p 0.471, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.22 (p 0.384, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.24 (p 0.328, n 18). could be the mix.
skeptic: leave-one-out range +0.09 to +0.26, sign flips 0; without severely affected donors +0.18 (p 0.471, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PLCG1 in astrocytes.

case closed: nothing better to follow up.

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