parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in proximal tubule cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	5 Parkinson's papers of 38	0.76
pathways Reactome	1 pathway; mostly immune signalling	0.90

No case: the score is under the bar. Receipt 13509

PILRB in astrocytes, braak+0.12 (p 0.761) → -0.20 (p 0.615)receipt 13515
PILRB in dopamine neurons, braak-0.26 (p 0.493) → -0.19 (p 0.618)receipt 13516

receipt 13516: PILRB in dopamine neurons, braak

power: full sample -0.28 (p 0.254, n 18), 95% CI -0.66 to +0.21. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.24 (p 0.346, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.40 (p 0.097, n 18). could be the mix.
skeptic: leave-one-out range -0.38 to -0.20, sign flips 0; without severely affected donors -0.28 (p 0.254, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PILRB in dopamine neurons.

case closed: nothing better to follow up.

receipt 13515: PILRB in astrocytes, braak

power: full sample +0.01 (p 0.983, n 18), 95% CI -0.46 to +0.47. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.02 (p 0.935, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.03 (p 0.922, n 18). could be the mix.
skeptic: leave-one-out range -0.14 to +0.10, sign flips 7; without severely affected donors +0.01 (p 0.983, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PILRB in astrocytes.

case closed: nothing better to follow up.

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