Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PIK3C2B

phosphatidylinositol-4-phosphate 3-kinase catalytic subunit type 2 beta

translation score 0.54, read 2026-10-25; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced in oligodendrocytes (175 nCPM)1.00
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		1 Parkinson's papers of 800.91
pathways
Reactome		1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 9548

Sealed predictions

  1. PIK3C2B in oligodendrocytes, braak-0.06 (p 0.873) → -0.74 (p 0.024)receipt 9555
  2. PIK3C2B in dopamine neurons, braak-0.46 (p 0.209) → -0.69 (p 0.038)receipt 9556

Swarm cases

receipt 9556: PIK3C2B in dopamine neurons, braak

power
full sample -0.52 (p 0.027, n 18), 95% CI -0.79 to -0.07. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.51 (p 0.031, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.62 (p 0.0060, n 18). not the mix.
skeptic
leave-one-out range -0.63 to -0.46, sign flips 0; without severely affected donors -0.52 (p 0.027, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PIK3C2B in dopamine neurons.

case closed: nothing better to follow up.

receipt 9555: PIK3C2B in oligodendrocytes, braak

power
full sample -0.43 (p 0.077, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.44 (p 0.070, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.38 (p 0.118, n 18). could be the mix.
skeptic
leave-one-out range -0.56 to -0.35, sign flips 0; without severely affected donors -0.43 (p 0.077, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PIK3C2B in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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