Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

PDGFB

platelet derived growth factor subunit B

translation score 0.41, read 2026-10-27; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including microglia; strongest in megakaryocytes0.75
chemistry
Open Targets		reachable by antibody: pegpleranib sodium0.45
trials
ClinicalTrials.gov		2 Parkinson's trials, 1 stopped0.60
literature
PubMed		31 Parkinson's papers of 2,3530.54
pathways
Reactome		8 pathways; mostly growth signalling0.60

No case: the score is under the bar. Receipt 11600

Sealed predictions

  1. PDGFB in dopamine neurons, braak-0.61 (p 0.084) → -0.25 (p 0.520)receipt 11607
  2. PDGFB in microglia, braak+0.07 (p 0.856) → -0.32 (p 0.400)receipt 11606

Swarm cases

receipt 11607: PDGFB in dopamine neurons, braak

power
full sample -0.48 (p 0.043, n 18), 95% CI -0.77 to -0.02. the interval excludes zero: something may be there, smaller than a half can see.
confounder
adjusted for sex: -0.50 (p 0.036, n 18). holds up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.60 (p 0.0086, n 18). not the mix.
skeptic
leave-one-out range -0.61 to -0.42, sign flips 0; without severely affected donors -0.48 (p 0.043, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDGFB in dopamine neurons.

case closed: nothing better to follow up.

receipt 11606: PDGFB in microglia, braak

power
full sample +0.01 (p 0.956, n 18), 95% CI -0.46 to +0.48. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: +0.04 (p 0.888, n 18). does not hold up.
composition
microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.04 (p 0.861, n 18). could be the mix.
skeptic
leave-one-out range -0.12 to +0.14, sign flips 6; without severely affected donors +0.01 (p 0.956, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for PDGFB in microglia.

case closed: nothing better to follow up.

Receipts

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