Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.07 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (rod photoreceptor cells) | 0.10 |
| chemistry Open Targets | compounds already reach it: pentoxifylline, dipyridamole | 1.00 |
| trials ClinicalTrials.gov | 1 Parkinson's trial, 0 stopped | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 3 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 3700
Sealed predictions
- PDE6G in dopamine neurons, braak-0.70 (p 0.036) → -0.38 (p 0.309)receipt 3706
Swarm cases
receipt 3706: PDE6G in dopamine neurons, braak
- power
- full sample -0.52 (p 0.028, n 18), 95% CI -0.79 to -0.07. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.48 (p 0.044, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.50 (p 0.036, n 18). not the mix.
- skeptic
- leave-one-out range -0.64 to -0.45, sign flips 0; without severely affected donors -0.52 (p 0.028, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PDE6G in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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