Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced in brain inhibitory neurons (646 nCPM) | 1.00 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 13334
Sealed predictions
- PCDH11X in dopamine neurons, braak+0.77 (p 0.015) → -0.02 (p 0.962)receipt 13341
Swarm cases
receipt 13341: PCDH11X in dopamine neurons, braak
- power
- full sample +0.34 (p 0.173, n 18), 95% CI -0.16 to +0.69. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.57 (p 0.013, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.60 (p 0.0086, n 18). not the mix.
- skeptic
- leave-one-out range +0.24 to +0.50, sign flips 0; without severely affected donors +0.34 (p 0.173, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for PCDH11X in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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