parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.03 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in pancreatic islet cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	41 Parkinson's papers of 4,098	0.51
pathways Reactome	5 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 7028

receipt 7036: PAX6 in dopamine neurons, braak

power: full sample -0.21 (p 0.403, n 18), 95% CI -0.62 to +0.28. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.715, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.19 (p 0.460, n 18). could be the mix.
skeptic: leave-one-out range -0.36 to -0.12, sign flips 0; without severely affected donors -0.21 (p 0.403, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PAX6 in dopamine neurons.

case closed: nothing better to follow up.

receipt 7035: PAX6 in astrocytes, braak

power: full sample +0.26 (p 0.294, n 18), 95% CI -0.23 to +0.65. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.24 (p 0.346, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.24 (p 0.328, n 18). could be the mix.
skeptic: leave-one-out range +0.16 to +0.37, sign flips 0; without severely affected donors +0.26 (p 0.294, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PAX6 in astrocytes.

case closed: nothing better to follow up.

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