parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in ependymal cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 16773

PAMR1 in astrocytes, braak+0.16 (p 0.680) → -0.58 (p 0.103)receipt 16780
PAMR1 in dopamine neurons, braak-0.40 (p 0.285) → +0.20 (p 0.607)receipt 16781

receipt 16781: PAMR1 in dopamine neurons, braak

power: full sample -0.13 (p 0.597, n 18), 95% CI -0.57 to +0.36. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.14 (p 0.573, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.14 (p 0.591, n 18). could be the mix.
skeptic: leave-one-out range -0.24 to -0.01, sign flips 0; without severely affected donors -0.13 (p 0.597, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PAMR1 in dopamine neurons.

case closed: nothing better to follow up.

receipt 16780: PAMR1 in astrocytes, braak

power: full sample -0.14 (p 0.591, n 18), 95% CI -0.57 to +0.35. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.11 (p 0.664, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.11 (p 0.664, n 18). could be the mix.
skeptic: leave-one-out range -0.27 to -0.03, sign flips 0; without severely affected donors -0.14 (p 0.591, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for PAMR1 in astrocytes.

case closed: nothing better to follow up.

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