Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | genetic association 0.33 (overall 0.20) | 0.33 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 2 Parkinson's papers of 246 | 0.85 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 2015
Sealed predictions
- P4HA1 in dopamine neurons, braak-0.21 (p 0.581) → +0.18 (p 0.639)receipt 2020
Swarm cases
receipt 2020: P4HA1 in dopamine neurons, braak
- power
- full sample -0.16 (p 0.526, n 18), 95% CI -0.58 to +0.33. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.25 (p 0.319, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.25 (p 0.310, n 18). could be the mix.
- skeptic
- leave-one-out range -0.30 to -0.06, sign flips 0; without severely affected donors -0.16 (p 0.526, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for P4HA1 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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