Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including microglia; strongest in choroid plexus epithelial cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 8 Parkinson's papers of 2,177 | 0.71 |
| pathways Reactome | 3 pathways; mostly immune signalling | 0.90 |
No case: the score is under the bar. Receipt 12971
Sealed predictions
- ORAI1 in dopamine neurons, braak-0.52 (p 0.151) → +0.23 (p 0.551)receipt 12980
- ORAI1 in microglia, braak+0.17 (p 0.663) → -0.60 (p 0.086)receipt 12979
Swarm cases
receipt 12980: ORAI1 in dopamine neurons, braak
- power
- full sample -0.17 (p 0.509, n 18), 95% CI -0.59 to +0.33. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.17 (p 0.509, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.31 (p 0.218, n 18). could be the mix.
- skeptic
- leave-one-out range -0.31 to -0.07, sign flips 0; without severely affected donors -0.17 (p 0.509, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ORAI1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 12979: ORAI1 in microglia, braak
- power
- full sample -0.18 (p 0.487, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.13 (p 0.609, n 18). does not hold up.
- composition
- microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.18 (p 0.476, n 18). could be the mix.
- skeptic
- leave-one-out range -0.32 to -0.08, sign flips 0; without severely affected donors -0.18 (p 0.487, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for ORAI1 in microglia.
case closed: nothing better to follow up.
Receipts
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