parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced in oligodendrocytes (6 nCPM)	1.00
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	1 Parkinson's papers of 18	0.91
pathways Reactome	2 pathways; mostly other	0.30

No case: the score is under the bar. Receipt 12690

OR2L13 in oligodendrocytes, braak+0.44 (p 0.238) → +0.05 (p 0.892)receipt 12696
OR2L13 in dopamine neurons, braak+0.18 (p 0.648) → +0.27 (p 0.476)receipt 12697

receipt 12697: OR2L13 in dopamine neurons, braak

power: full sample +0.21 (p 0.403, n 18), 95% CI -0.28 to +0.62. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.21 (p 0.393, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.23 (p 0.360, n 18). could be the mix.
skeptic: leave-one-out range +0.11 to +0.33, sign flips 0; without severely affected donors +0.21 (p 0.403, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for OR2L13 in dopamine neurons.

case closed: nothing better to follow up.

receipt 12696: OR2L13 in oligodendrocytes, braak

power: full sample +0.11 (p 0.671, n 18), 95% CI -0.38 to +0.55. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.10 (p 0.702, n 18). does not hold up.
composition: oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: +0.06 (p 0.827, n 18). could be the mix.
skeptic: leave-one-out range -0.02 to +0.27, sign flips 1; without severely affected donors +0.11 (p 0.671, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for OR2L13 in oligodendrocytes.

case closed: nothing better to follow up.

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