Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.27 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 876 | 0.91 |
| pathways Reactome | 37 pathways; mostly protein handling | 0.90 |
No case: the score is under the bar. Receipt 15585
Sealed predictions
- NUP98 in dopamine neurons, braak+0.47 (p 0.204) → -0.01 (p 0.982)receipt 15592
Swarm cases
receipt 15592: NUP98 in dopamine neurons, braak
- power
- full sample +0.32 (p 0.198, n 18), 95% CI -0.17 to +0.68. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.28 (p 0.254, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.31 (p 0.218, n 18). could be the mix.
- skeptic
- leave-one-out range +0.24 to +0.46, sign flips 0; without severely affected donors +0.32 (p 0.198, n 18). fragile.
- cell type
- strongest in microglia: +0.78 (p 1.6e-4, n 18) vs +0.32 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NUP98 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up NUP98 · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.00 p 1.000 (needs p < 1.5e-4)
Receipts
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