Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 61 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 11959
Sealed predictions
- NUCB1 in dopamine neurons, braak-0.46 (p 0.209) → -0.17 (p 0.656)receipt 11966
Swarm cases
receipt 11966: NUCB1 in dopamine neurons, braak
- power
- full sample -0.29 (p 0.235, n 18), 95% CI -0.67 to +0.20. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.29 (p 0.243, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.36 (p 0.142, n 18). could be the mix.
- skeptic
- leave-one-out range -0.49 to -0.20, sign flips 0; without severely affected donors -0.29 (p 0.235, n 18). fragile.
- cell type
- strongest in oligodendrocytes: -0.70 (p 0.0013, n 18) vs -0.29 in dopamine neurons. proposing oligodendrocytes.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NUCB1 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up NUCB1 · oligodendrocytes · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) +0.18 p 0.534 (needs p < 1.8e-4)
Receipts
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