parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.05 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in ependymal cells	0.75
chemistry Open Targets	reachable by antibody	0.45
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 5472

receipt 5481: NSMF in dopamine neurons, braak

power: full sample -0.11 (p 0.671, n 18), 95% CI -0.55 to +0.38. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.15 (p 0.561, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.29 (p 0.246, n 18). could be the mix.
skeptic: leave-one-out range -0.24 to +0.00, sign flips 2; without severely affected donors -0.11 (p 0.671, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NSMF in dopamine neurons.

case closed: nothing better to follow up.

receipt 5480: NSMF in astrocytes, braak

power: full sample -0.59 (p 0.010, n 18), 95% CI -0.83 to -0.17. the interval excludes zero: something may be there, smaller than a half can see.
confounder: adjusted for sex: -0.59 (p 0.010, n 18). holds up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.61 (p 0.0067, n 18). not the mix.
skeptic: leave-one-out range -0.71 to -0.53, sign flips 0; without severely affected donors -0.59 (p 0.010, n 18). robust.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NSMF in astrocytes.

case closed: nothing better to follow up.

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