Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.04 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including oligodendrocyte progenitor cells; strongest in adrenal cortex cells | 0.75 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 350 | 0.91 |
| pathways Reactome | 1 pathway; mostly other | 0.30 |
No case: the score is under the bar. Receipt 6255
Sealed predictions
- NR0B1 in oligodendrocytes, braak-0.21 (p 0.586) → -0.33 (p 0.393)receipt 6263
- NR0B1 in dopamine neurons, braak+0.04 (p 0.924) → -0.11 (p 0.787)receipt 6264
Swarm cases
receipt 6264: NR0B1 in dopamine neurons, braak
- power
- full sample -0.11 (p 0.658, n 18), 95% CI -0.55 to +0.37. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.08 (p 0.767, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.11 (p 0.658, n 18). could be the mix.
- skeptic
- leave-one-out range -0.22 to +0.00, sign flips 2; without severely affected donors -0.11 (p 0.658, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NR0B1 in dopamine neurons.
case closed: nothing better to follow up.
receipt 6263: NR0B1 in oligodendrocytes, braak
- power
- full sample -0.26 (p 0.298, n 18), 95% CI -0.65 to +0.24. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.53 (p 0.025, n 18). holds up.
- composition
- oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.29 (p 0.250, n 18). could be the mix.
- skeptic
- leave-one-out range -0.39 to -0.15, sign flips 0; without severely affected donors -0.26 (p 0.298, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NR0B1 in oligodendrocytes.
case closed: nothing better to follow up.
Receipts
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