parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.06 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in bergmann glia	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	4 Parkinson's papers of 98	0.79
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 4458

receipt 4466: NPAS3 in dopamine neurons, braak

power: full sample +0.24 (p 0.341, n 18), 95% CI -0.26 to +0.63. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.25 (p 0.310, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.25 (p 0.319, n 18). could be the mix.
skeptic: leave-one-out range +0.16 to +0.39, sign flips 0; without severely affected donors +0.24 (p 0.341, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NPAS3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 4465: NPAS3 in astrocytes, braak

power: full sample +0.27 (p 0.273, n 18), 95% CI -0.22 to +0.66. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.25 (p 0.310, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.25 (p 0.310, n 18). could be the mix.
skeptic: leave-one-out range +0.19 to +0.35, sign flips 0; without severely affected donors +0.27 (p 0.273, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NPAS3 in astrocytes.

case closed: nothing better to follow up.

loading the receipts