Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | group enriched outside the brain (vascular endothelial cells) | 0.10 |
| chemistry Open Targets | a small-molecule pocket | 0.60 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 787 | 0.91 |
| pathways Reactome | 8 pathways; mostly vesicle traffic | 1.00 |
No case: the score is under the bar. Receipt 11740
Sealed predictions
- NOTCH4 in dopamine neurons, braak-0.84 (p 0.004) → -0.24 (p 0.539)receipt 11749
Swarm cases
receipt 11749: NOTCH4 in dopamine neurons, braak
- power
- full sample -0.54 (p 0.020, n 18), 95% CI -0.81 to -0.10. the interval excludes zero: something may be there, smaller than a half can see.
- confounder
- adjusted for sex: -0.54 (p 0.020, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.61 (p 0.0075, n 18). not the mix.
- skeptic
- leave-one-out range -0.62 to -0.49, sign flips 0; without severely affected donors -0.54 (p 0.020, n 18). robust.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NOTCH4 in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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