parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in adrenal cortex cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 13684

NIPSNAP3B in dopamine neurons, braak+0.50 (p 0.168) → -0.07 (p 0.856)receipt 13692
NIPSNAP3B in microglia, braak+0.10 (p 0.790) → +0.50 (p 0.173)receipt 13691

receipt 13692: NIPSNAP3B in dopamine neurons, braak

power: full sample +0.15 (p 0.555, n 18), 95% CI -0.34 to +0.58. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.14 (p 0.585, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.11 (p 0.658, n 18). could be the mix.
skeptic: leave-one-out range +0.04 to +0.28, sign flips 0; without severely affected donors +0.15 (p 0.555, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NIPSNAP3B in dopamine neurons.

case closed: nothing better to follow up.

receipt 13691: NIPSNAP3B in microglia, braak

power: full sample +0.29 (p 0.239, n 18), 95% CI -0.20 to +0.67. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.30 (p 0.221, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: +0.32 (p 0.198, n 18). could be the mix.
skeptic: leave-one-out range +0.21 to +0.49, sign flips 0; without severely affected donors +0.29 (p 0.239, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NIPSNAP3B in microglia.

case closed: nothing better to follow up.

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