Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | expressed broadly, no clear home in brain cells | 0.40 |
| chemistry Open Targets | hard to drug | 0.00 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15072
Sealed predictions
- NFIC in dopamine neurons, braak-0.36 (p 0.347) → -0.53 (p 0.143)receipt 15079
Swarm cases
receipt 15079: NFIC in dopamine neurons, braak
- power
- full sample -0.46 (p 0.056, n 18), 95% CI -0.76 to +0.01. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.48 (p 0.042, n 18). holds up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.54 (p 0.021, n 18). not the mix.
- skeptic
- leave-one-out range -0.59 to -0.39, sign flips 0; without severely affected donors -0.46 (p 0.056, n 18). robust.
- cell type
- strongest in microglia: -0.62 (p 0.0064, n 18) vs -0.46 in dopamine neurons. proposing microglia.
- axis
- no measure beats "tracks Braak Lewy-body stage" for NFIC in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up NFIC · microglia · braak: substantia nigra, an independent cohort (Parkinson's or LBD vs controls) -0.45 p 0.110 (needs p < 1.5e-4)
Receipts
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