parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	genetic association 0.04 (overall 0.03)	0.04
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in late primary spermatocytes	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 6931

receipt 6938: NAA11 in dopamine neurons, braak

power: full sample +0.39 (p 0.107, n 18), 95% CI -0.09 to +0.73. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.37 (p 0.135, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.42 (p 0.086, n 18). could be the mix.
skeptic: leave-one-out range +0.32 to +0.51, sign flips 0; without severely affected donors +0.39 (p 0.107, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NAA11 in dopamine neurons.

case closed: nothing better to follow up.

receipt 6937: NAA11 in astrocytes, braak

power: full sample +0.17 (p 0.509, n 18), 95% CI -0.33 to +0.59. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.15 (p 0.555, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.13 (p 0.597, n 18). could be the mix.
skeptic: leave-one-out range +0.04 to +0.33, sign flips 0; without severely affected donors +0.17 (p 0.509, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for NAA11 in astrocytes.

case closed: nothing better to follow up.

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