parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.01 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in cytotrophoblasts	0.75
chemistry Open Targets	a small-molecule pocket	0.60
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	19 Parkinson's papers of 87	0.61
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 8856

receipt 8865: MYORG in dopamine neurons, braak

power: full sample -0.03 (p 0.894, n 18), 95% CI -0.49 to +0.44. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.983, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.06 (p 0.807, n 18). could be the mix.
skeptic: leave-one-out range -0.19 to +0.09, sign flips 5; without severely affected donors -0.03 (p 0.894, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MYORG in dopamine neurons.

case closed: nothing better to follow up.

receipt 8864: MYORG in astrocytes, braak

power: full sample -0.05 (p 0.847, n 18), 95% CI -0.50 to +0.43. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.01 (p 0.969, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.00 (p 0.990, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.02, sign flips 5; without severely affected donors -0.05 (p 0.847, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MYORG in astrocytes.

case closed: nothing better to follow up.

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