Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.00 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enhanced, including astrocytes; strongest in renal collecting duct intercalated cells | 0.75 |
| chemistry Open Targets | reachable by antibody | 0.45 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | 1 Parkinson's papers of 49 | 0.91 |
| pathways Reactome | 2 pathways; mostly other | 0.30 |
No case: the score is under the bar. Receipt 15695
Sealed predictions
- MYO19 in dopamine neurons, braak-0.70 (p 0.035) → +0.09 (p 0.813)receipt 15703
- MYO19 in astrocytes, braak-0.25 (p 0.518) → -0.25 (p 0.514)receipt 15702
Swarm cases
receipt 15703: MYO19 in dopamine neurons, braak
- power
- full sample -0.34 (p 0.167, n 18), 95% CI -0.70 to +0.15. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.34 (p 0.173, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.42 (p 0.082, n 18). could be the mix.
- skeptic
- leave-one-out range -0.48 to -0.25, sign flips 0; without severely affected donors -0.34 (p 0.167, n 18). fragile.
- cell type
- strongest in OPCs: -0.75 (p 3.7e-4, n 18) vs -0.34 in dopamine neurons. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MYO19 in dopamine neurons.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up MYO19 · OPCs · braak: substantia nigra, an independent cohort (already registered)
receipt 15702: MYO19 in astrocytes, braak
- power
- full sample -0.18 (p 0.482, n 18), 95% CI -0.59 to +0.32. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: -0.21 (p 0.403, n 18). does not hold up.
- composition
- astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: -0.28 (p 0.254, n 18). could be the mix.
- skeptic
- leave-one-out range -0.34 to -0.07, sign flips 0; without severely affected donors -0.18 (p 0.482, n 18). fragile.
- cell type
- strongest in OPCs: -0.75 (p 3.7e-4, n 18) vs -0.18 in astrocytes. proposing OPCs.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MYO19 in astrocytes.
follow-up registered; not confirmed in substantia nigra, an independent cohort.
follow-up MYO19 · OPCs · braak: substantia nigra, an independent cohort: not measured
Receipts
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