Six readers
| reader | found | score |
|---|---|---|
| genetics Open Targets | no genetic evidence; overall 0.01 from other evidence | 0.00 |
| cell type Human Protein Atlas | cell type enriched outside the brain (prostatic glandular cells) | 0.10 |
| chemistry Open Targets | reachable by antibody | 0.36 |
| trials ClinicalTrials.gov | no Parkinson's trials on record: an open field | 1.00 |
| literature PubMed | no papers tie it to Parkinson's yet | 1.00 |
| pathways Reactome | in no curated pathway | 0.00 |
No case: the score is under the bar. Receipt 10869
Sealed predictions
- MSMB in dopamine neurons, braak+0.00 (p 1.000) → -0.07 (p 0.857)receipt 10878
Swarm cases
receipt 10878: MSMB in dopamine neurons, braak
- power
- full sample +0.06 (p 0.827, n 18), 95% CI -0.42 to +0.51. the interval is wide: not enough donors to tell.
- confounder
- adjusted for sex: +0.01 (p 0.962, n 18). does not hold up.
- composition
- dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: +0.02 (p 0.942, n 18). could be the mix.
- skeptic
- leave-one-out range -0.02 to +0.20, sign flips 4; without severely affected donors +0.06 (p 0.827, n 18). fragile.
- cell type
- no other cell group does better.
- axis
- no measure beats "tracks Braak Lewy-body stage" for MSMB in dopamine neurons.
case closed: nothing better to follow up.
Receipts
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