parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including microglia; strongest in ependymal cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	no Parkinson's trials on record: an open field	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	1 pathway; mostly other	0.30

No case: the score is under the bar. Receipt 15788

receipt 15796: MSH5 in dopamine neurons, braak

power: full sample -0.35 (p 0.156, n 18), 95% CI -0.70 to +0.14. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.35 (p 0.156, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.48 (p 0.044, n 18). not the mix.
skeptic: leave-one-out range -0.45 to -0.26, sign flips 0; without severely affected donors -0.35 (p 0.156, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MSH5 in dopamine neurons.

case closed: nothing better to follow up.

receipt 15795: MSH5 in microglia, braak

power: full sample -0.09 (p 0.715, n 18), 95% CI -0.54 to +0.39. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.09 (p 0.715, n 18). does not hold up.
composition: microglia share of nuclei vs axis -0.11 (p 0.652); controlling for it: -0.07 (p 0.794, n 18). could be the mix.
skeptic: leave-one-out range -0.20 to +0.04, sign flips 2; without severely affected donors -0.09 (p 0.715, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MSH5 in microglia.

case closed: nothing better to follow up.

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