parkinson, Parkinson's research notebook

Six readers

reader	found	score
genetics Open Targets	no genetic evidence; overall 0.00 from other evidence	0.00
cell type Human Protein Atlas	cell type enhanced, including astrocytes; strongest in sertoli cells	0.75
chemistry Open Targets	hard to drug	0.00
trials ClinicalTrials.gov	1 Parkinson's trial, 0 stopped	1.00
literature PubMed	no papers tie it to Parkinson's yet	1.00
pathways Reactome	in no curated pathway	0.00

No case: the score is under the bar. Receipt 15931

receipt 15938: MRO in dopamine neurons, braak

power: full sample -0.06 (p 0.814, n 18), 95% CI -0.51 to +0.42. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: -0.11 (p 0.652, n 18). does not hold up.
composition: dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.21 (p 0.408, n 18). could be the mix.
skeptic: leave-one-out range -0.19 to +0.07, sign flips 5; without severely affected donors -0.06 (p 0.814, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MRO in dopamine neurons.

case closed: nothing better to follow up.

receipt 15937: MRO in astrocytes, braak

power: full sample +0.18 (p 0.471, n 18), 95% CI -0.31 to +0.60. the interval is wide: not enough donors to tell.
confounder: adjusted for sex: +0.18 (p 0.487, n 18). does not hold up.
composition: astrocytes share of nuclei vs axis -0.21 (p 0.413); controlling for it: +0.18 (p 0.471, n 18). could be the mix.
skeptic: leave-one-out range +0.07 to +0.36, sign flips 0; without severely affected donors +0.18 (p 0.471, n 18). fragile.
cell type: no other cell group does better.
axis: no measure beats "tracks Braak Lewy-body stage" for MRO in astrocytes.

case closed: nothing better to follow up.

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