Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

MICAL3

microtubule associated monooxygenase, calponin and LIM domain containing 3

translation score 0.46, read 2026-10-26; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.01 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in choroid plexus epithelial cells0.75
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		2 Parkinson's papers of 320.85
pathways
Reactome		in no curated pathway0.00

No case: the score is under the bar. Receipt 11065

Sealed predictions

  1. MICAL3 in dopamine neurons, braak-0.50 (p 0.170) → -0.52 (p 0.150)receipt 11074
  2. MICAL3 in oligodendrocytes, braak-0.17 (p 0.663) → -0.53 (p 0.143)receipt 11073

Swarm cases

receipt 11074: MICAL3 in dopamine neurons, braak

power
full sample -0.33 (p 0.185, n 18), 95% CI -0.69 to +0.16. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.32 (p 0.194, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.32 (p 0.201, n 18). could be the mix.
skeptic
leave-one-out range -0.42 to -0.24, sign flips 0; without severely affected donors -0.33 (p 0.185, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MICAL3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 11073: MICAL3 in oligodendrocytes, braak

power
full sample -0.31 (p 0.204, n 18), 95% CI -0.68 to +0.18. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.39 (p 0.114, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.42 (p 0.084, n 18). could be the mix.
skeptic
leave-one-out range -0.42 to -0.23, sign flips 0; without severely affected donors -0.31 (p 0.204, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MICAL3 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

loading the receipts