Braak stage 1, 100% of pigmented neurons left
parkinsonconnecting

Gene record

MGAT3

beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase

translation score 0.52, read 2026-10-28; 2 sealed predictions, 0 held; 3 receipts.

Six readers

readerfoundscore
genetics
Open Targets		no genetic evidence; overall 0.00 from other evidence0.00
cell type
Human Protein Atlas		cell type enhanced, including oligodendrocytes; strongest in enterocytes0.75
chemistry
Open Targets		a small-molecule pocket0.60
trials
ClinicalTrials.gov		no Parkinson's trials on record: an open field1.00
literature
PubMed		no papers tie it to Parkinson's yet1.00
pathways
Reactome		1 pathway; mostly other0.30

No case: the score is under the bar. Receipt 13260

Sealed predictions

  1. MGAT3 in dopamine neurons, braak-0.41 (p 0.276) → -0.53 (p 0.146)receipt 13268
  2. MGAT3 in oligodendrocytes, braak+0.14 (p 0.718) → -0.90 (p 0.001)receipt 13267

Swarm cases

receipt 13268: MGAT3 in dopamine neurons, braak

power
full sample -0.31 (p 0.214, n 18), 95% CI -0.68 to +0.19. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.33 (p 0.176, n 18). does not hold up.
composition
dopamine neurons share of nuclei vs axis +0.05 (p 0.854); controlling for it: -0.33 (p 0.185, n 18). could be the mix.
skeptic
leave-one-out range -0.44 to -0.21, sign flips 0; without severely affected donors -0.31 (p 0.214, n 18). fragile.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MGAT3 in dopamine neurons.

case closed: nothing better to follow up.

receipt 13267: MGAT3 in oligodendrocytes, braak

power
full sample -0.43 (p 0.077, n 18), 95% CI -0.75 to +0.05. the interval is wide: not enough donors to tell.
confounder
adjusted for sex: -0.42 (p 0.086, n 18). does not hold up.
composition
oligodendrocytes share of nuclei vs axis +0.03 (p 0.915); controlling for it: -0.48 (p 0.046, n 18). not the mix.
skeptic
leave-one-out range -0.61 to -0.35, sign flips 0; without severely affected donors -0.43 (p 0.077, n 18). robust.
cell type
no other cell group does better.
axis
no measure beats "tracks Braak Lewy-body stage" for MGAT3 in oligodendrocytes.

case closed: nothing better to follow up.

Receipts

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